Table 2.

Mechanical parameter values.

Parameter	Name	Value
$\varphi$	Porosity	0.2
K	Bulk modulus	40,000 (Pa) [19] ${}^{†}$
G	Shear modulus	30,000 (Pa) [19] ${}^{†}$
$\alpha$	Biot effective stress coefficient	0.7 [20] ${}^{‡}$
$\kappa$	Hydraulic conductivity	$6.9\times {10}^{-14}$ (${\mathrm{m}}^2·{\mathrm{Pa}}^{-1}·{\mathrm{s}}^{-1}$) [19] ${}^{†}$
M	Biot modulus	$2\times {10}^5$ (Pa) [20] ${}^{‡}$
$D_{cell}$	Diffusion coefficient for cells	$3.6\times {10}^{-8}({\mathrm{cm}}^2·{\mathrm{h}}^{-1})$ [21]
$D_{cyto}$	Diffusion coefficient for cytokines	$5.2\times {10}^{-5}({\mathrm{cm}}^2·{\mathrm{h}}^{-1})$ [22]
$D_H$	Diffusion coefficient for HMGB1	$3.3\times {10}^{-3}({\mathrm{cm}}^2·{\mathrm{h}}^{-1})$ [23]

^† These values are for sarcoma, not necessarily osteosarcoma; ^‡ These values are for generic tumors, evaluated through Artificial Neural Network (ANN) and then averaged among all reasonable values.