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Regulation pathway of NCLX by CKII and its implication in controlling neuronal plasticity of the axon initial Scheme 2. efflux. CKII phosphorylation also participates in the allosteric regulation of NCLX-dependent Ca2+ transport by ΔΨm. The link between CKII and NCLX is critical for controlling ultrafast AIS plasticity. Knocking down of NCLX eliminates the physical and functional translocation of the axon initial segment linked to this process.
