Table 3.
Pathological and molecular features, median [IQR], and % (n).
| Feature | LOCRC | EOCRC | p |
|---|---|---|---|
| Number of patients | 1650 | 423 | |
| Tumor regression (Dworak classification) | 0.019 | ||
| Dworak 0 | 4% (17) | 11% (14) | |
| Dworak 1 | 20% (86) | 23% (31) | |
| Dworak 2 | 24% (103) | 29% (38) | |
| Dworak 3 | 35% (150) | 25% (33) | |
| Dworak 4 | 17% (73) | 12% (16) | |
| Major or complete response to neoadjuvant therapy | 24% (103) | 34% (45) | 0.005 |
| Tumoral stage, AJCC 8th edition | <0.0001 | ||
| Stage 0 | 5% (70) | 5% (16) | |
| Stage I | 26% (428) | 18% (61) | |
| Stage II | 29% (476) | 19% (65) | |
| Stage III | 25% (414) | 25% (86) | |
| Stage IV | 15% (248) | 33% (116) | |
| Tumoral stage | 0.064 | ||
| 0 | 5% (82) | 6% (20) | |
| 1 | 14% (215) | 11% (39) | |
| 2 | 19% (319) | 14% (50) | |
| 3 | 50% (818) | 52% (178) | |
| 4 | 12% (202) | 17% (57) | |
| Node stage | <0.0001 | ||
| 0 | 61% (1002) | 48% (165) | |
| 1c | 2% (38) | 2% (6) | |
| 1 | 24% (385) | 25% (87) | |
| 2 | 13% (211) | 25% (86) | |
| Metastasis stage | <0.0001 | ||
| 0 | 85% (1388) | 66% (228) | |
| 1 | 15% (248) | 34% (116) | |
| Number of harvested lymph nodes | 22 [17–29] | 23 [19–34] | 0.0002 |
| Lymph nodes ratio | 0.10 [0.05–0.22] | 0.29 [0.07–1.00] | <0.0001 |
| Mucinous tumor | 15% (249) | 17% (57) | 0.513 |
| Signet-ring cells phenotype | 1% (25) | 3% (9) | 0.169 |
| Extramural invasion | 27% (441) | 22% (76) | 0.068 |
| Lymphovascular invasion | 33% (594) | 27% (93) | 0.026 |
| Perineural invasion | 12% (197) | 16% (54) | 0.074 |
| Tumor differentiation | <0.0001 | ||
| Grade 0 | 1% (18) | 1% (1) | |
| Grade 1 | 2% (30) | 1% (6) | |
| Grade 2 | 44% (726) | 38% (131) | |
| Grade 3 | 36% (586) | 28% (98) | |
| Grade 4 | 1% (17) | 1% (1) | |
| Not determinable | 16% (256) | 31% (107) | |
| Resection margins | 0.090 | ||
| R0 | 98% (1604) | 99% (343) | |
| R1 | 1.9% (31) | 1% (1) | |
| R2 | 0.1% (1) | -- | |
| Microsatellite Instability | 6% (99) | 4% (17) | 0.113 |
| Mutations ‡ | 13% (203) | 51% (78) | <0.0001 |
Abbreviations: IQR, interquartile range; LOCRC, late-onset colorectal cancer; EOCRC, early-onset colorectal cancer; BMI, body mass index; AJCC, American Joint Committee on Cancer. Continuous data are analyzed with unpaired two-sided T- or Mann–Whitney tests; dichotomous and categorical data are analyzed with Pearson’s χ2-test and Fisher’s exact test; ‡ On 1707 (LOCRC = 1554; EOCRC = 153) analyzed patients.