Table 6.
Cox proportional hazard regression analysis on RFS of stage I patients.
| Univariable Analysis | Multivariable Analysis | |||||
|---|---|---|---|---|---|---|
| Variable | HR | 95% CI | p | HR | 95% CI | p |
| Age of onset (vs. LOCRC) | 2.68 | 1.07–6.72 | 0.035 | 2.49 | 1.19–5.23 | 0.016 |
| Gender (vs. males) | 0.52 | 0.25–1.07 | 0.079 | -- | -- | -- |
| Obesity (BMI ≥ 30 Kg/m2) | 0.91 | 0.38–2.18 | 0.828 | -- | -- | -- |
| Smoking (vs. non-smokers) | 0.246 | -- | -- | -- | ||
| Current smokers | 1.23 | 0.49–3.08 | 0.656 | -- | -- | -- |
| Ex-smokers | 1.87 | 0.89–3.91 | 0.094 | -- | -- | -- |
| Tumor location (vs. right colon) | 0.452 | -- | -- | -- | ||
| Left colon | 0.54 | 0.18–1.65 | 0.277 | -- | -- | -- |
| Rectum | 0.98 | 0.44–2.19 | 0.964 | -- | -- | -- |
| Synchronous tumors | 3.08 | 0.74–12.88 | 0.123 | -- | -- | -- |
| Family history of CRC | 0.32 | 0.10–1.06 | 0.063 | -- | -- | -- |
| Postoperative reoperation | 0.62 | 0.13–3.00 | 0.551 | -- | -- | -- |
| Mucinous tumors | 0.84 | 0.26–2.74 | 0.775 | -- | -- | -- |
| Extramural invasion | 3.17 | 0.96–10.46 | 0.057 | -- | -- | -- |
| Lymphovascular invasion | 1.10 | 0.39–3.12 | 0.852 | -- | -- | -- |
| Perineural invasion | 3.01 | 0.41–22.08 | 0.277 | -- | -- | -- |
Abbreviations: R/PFS, recurrence/progression-free survival; HR, hazard ratio; CI, confidence intervals; LOCRC, late-onset colorectal cancer; BMI, body mass index; CRC, colorectal cancer.