Table 3.
Synopsis of the results from the multivariable Cox regression for RFS and cumulative recurrence rates according to metformin use and diabetes in the complete cohort.
| Multivariable Cox Regression * | ||||
|---|---|---|---|---|
| Complete Cohort | p | Hazard Ratio | Lower 95%-CI | Upper 95%-CI |
| Recurrence-free survival | ||||
| Metformin yes vs. no | 0.024 | 0.396 | 0.177 | 0.884 |
| Diabetes yes vs. no | 0.021 | 1.980 | 1.108 | 3.538 |
| Cumulative recurrence rate | ||||
| Metformin yes vs. no | 0.061 | 0.325 | 0.100 | 1.054 |
| Diabetes yes vs. no | 0.141 | 1.915 | 0.807 | 4.547 |
| Cumulative locoregional recurrence rate | ||||
| Metformin yes vs. no | 0.008 | 0.135 | 0.031 | 0.589 |
| Diabetes yes vs. no | 0.003 | 4.173 | 1.628 | 10.697 |
| Cumulative distant recurrence rate | ||||
| Metformin yes vs. no | 0.702 | 1.356 | 0.286 | 6.426 |
| Diabetes yes vs. no | 0.124 | 0.370 | 0.104 | 1.312 |
* adjusted for age at diagnosis, body mass index, statin use, ASA, tumor size, nodal status, ulceration, and histologic type (both metformin and diabetes included in the model).