Table 4.
Synopsis of the results from the multivariable Cox regression for RFS and cumulative recurrence rates according to metformin use in the diabetes complete cohort.
| Multivariable Cox Regression * | ||||
|---|---|---|---|---|
| Diabetes Cohort | p | Hazard Ratio | Lower 95%-CI | Upper 95%-CI |
| Recurrence-free survival | ||||
| Metformin yes vs. no | 0.032 | 0.352 | 0.135 | 0.913 |
| Cumulative recurrence rate | ||||
| Metformin yes vs. no | 0.869 | 0.855 | 0.133 | 5.479 |
| Cumulative locoregional recurrence rate | ||||
| Metformin yes vs. no | 0.964 | 0.952 | 0.109 | 8.305 |
| Cumulative distant recurrence rate | ||||
| Metformin yes vs. no | - & | - | - | - |
* adjusted for age at diagnosis, body mass index, statin use, ASA, tumor size, nodal status, ulceration, and histologic type (both metformin and diabetes included in the model); & due to the small number of events, the model did not converge.