Table 3.

Enrichment analysis of up-regulated DEGs. (A) Biological pathway. (B) Cellular component.

(A)
Biological Pathway	No. of Genes in the Dataset	Percentage of Genes	Fold Enrichment	p-Value (Bonferroni Method)	Genes Mapped (from Input Data Set)
Mitotic M-M/G1 phases	11	27.5	7.152153	0.000313	MCM2; CDC20; AURKB; MCM4; CDC7; BIRC5; KIF2C; MCM10; UBE2C; BUB1; CENPF;
2/M Checkpoints	6	15	21.96786	0.000383	MCM2; MCM4; CDC7; MCM10; CCNB2; CHEK1;
Cell Cycle, Mitotic	12	30	5.955975	0.000568	MCM2; CDC20; AURKB; MCM4; CDC7; BIRC5; KIF2C; MCM10; CCNB2; UBE2C; BUB1; CENPF;
DNA Replication	11	27.5	6.631518	0.000672	MCM2; CDC20; AURKB; MCM4; CDC7; BIRC5; KIF2C; MCM10; UBE2C; BUB1; CENPF;
Cell Cycle Checkpoints	8	20	10.67079	0.000939	MCM2; CDC20; MCM4; CDC7; MCM10; CCNB2; CHEK1; UBE2C;
G2/M DNA damage checkpoint	5	12.5	27.15018	0.001423	MCM2; MCM4; CDC7; MCM10; CHEK1;
Mitotic Prometaphase	7	17.5	11.13068	0.003929	CDC20; AURKB; BIRC5; KIF2C; UBE2C; BUB1; CENPF;
Activation of ATR in response to replication stress	5	12.5	21.28146	0.005033	MCM2; MCM4; CDC7; MCM10; CHEK1;
FOXM1 transcription factor network	5	12.5	18.74856	0.009595	AURKB; BIRC5; FOXM1; CCNB2; CENPF;
(B)
Cellular Component	No. of Genes in the Dataset	Percentage of Genes	Fold Enrichment	p -Value (Bonferroni Method)	Genes Mapped (from Input Data Set)
Chromosome	5	7.462687	18.4384887	0.005756	MCM2; AURKB; MCM4; BIRC5; BUB1;
Nucleoplasm	10	14.92537	4.84162639	0.028453	CHAF1B; MCM2; CDC20; MCM4; CDC7; FANCD2; WDR4; MCM10; CHEK1; UBE2C;
Chromosome passenger complex	2	2.985075	145.024966	0.048965	AURKB; BIRC5;