Table 4.
Enrichment analysis of down-regulated DEGs. (A) Biological pathway. (B) Cellular component. (C) Molecular function.
| (A) | |||||
| Biological Pathway | No. of Genes in the Dataset | Percentage of Genes | Fold Enrichment | p-Value (Bonferroni Method) | Genes Mapped (from Input Data Set) |
| Epithelial-to-mesenchymal transition | 17 | 31.48148 | 10.70746 | 1.34E-10 | SFRP4; ECM2; DCN; SPARCL1; CXCL12; F13A1; COL14A1; LHFP; ZCCHC24; RUNX1T1; AKAP12; EFEMP1; DPT; SRPX; JAM2; MFAP4; IGF1; |
| (B) | |||||
| Cellular Component | No. of Genes in the Dataset | Percentage of Genes | Fold Enrichment | p-Value (Bonferroni Method) | genes MAPPED (from Input Data Set) |
| Extracellular | 36 | 39.56044 | 3.15516144 | 5.15E-08 | SCGB2A2; SCGB1D2; TFF1; TFF3; HTRA1; AGR3; SFRP4; PIP; ECM2; CPB1; LAMA2; IGFBP4; NTN4; CCDC80; DCN; SPARCL1; CXCL12; SMOC2; SCUBE2; IL6ST; F13A1; STC2; COL14A1; PDGFD; SEPP1; APOD; SEMA3C; GHR; EFEMP1; DPT; SRPX; OGN; CFD; MFAP4; IGF1; ZBTB16; |
| Extracellular space | 13 | 14.28571 | 5.1493083 | 0.001012 | SCGB1D2; ABI3BP; HTRA1; SFRP4; DCN; IL6ST; COL14A1; APOD; GHR; EFEMP1; DPT; OGN; IGF1; |
| Extracellular matrix | 8 | 8.791209 | 10.6728104 | 0.000636 | ABI3BP; HTRA1; DCN; COL14A1; EFEMP1; DPT; OGN; MFAP4; |
| (C) | |||||
| Molecular Function | No. of Genes in the Dataset | Percentage of Genes | Fold Enrichment | p-Value (Bonferroni Method) | Genes Mapped (from Input Data Set) |
| Extracellular matrix structural constituent | 8 | 8.510638 | 9.30256 | 0.000534 | ECM2; LAMA2; NTN4; DCN; COL14A1; EFEMP1; DPT; MFAP4; |
| Carboxypeptidase activity | 3 | 3.191489 | 27.62133 | 0.037609 | CPB1; CPA3; CPE; |