Table 3.
GRADE evidence table summarizing the relevant risk factors for tumor recurrence.
| Certainty Assessment | No. of Patients | Effect | Certainty | Significance and Importance |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number of Studies | Mean Follow-Up (mos) | Study Design | Risk of Bias | Inconsistency | Indirectness | Imprecision | Other Considerations | Simpson Grade 1 | Simpson Grade 2 | Relative (95% CI) | Absolute (95% CI) | ||
| (1) Simpson grades 1 or 2 vs. Simpson grades 3, 4 or 5 resection of spinal meningiomas | |||||||||||||
| 25 | 62.4 | Observational studies | Not serious | Not serious | Not serious | Not serious | Very strong association | 41/1326 (3.1%) | 74/266 (27.8%) | OR 0.08 (0.04 to 0.15) | 248 fewer per 1000 (from 263 fewer to 224 fewer) | ⨁⨁⨁⨁High | SIGNIFICANT, CRITICAL |
| (2) WHO grade 1 vs. WHO grade 2 or 3 spinal meningiomas | |||||||||||||
| 22 | 53.2 | Observational studies | Not serious | Not serious | Not serious | Not serious | Very strong association | 83/1591 (5.2%) | 32/69 (46.4%) | OR 0.09 (0.04 to 0.21) | 392 fewer per 1000 (from 430 fewer to 310 fewer) | ⨁⨁⨁⨁High | SIGNIFICANT, CRITICAL |
| (3) Ventral vs. non-ventral spinal meningiomas | |||||||||||||
| 9 | 70.9 | Observational studies | Not serious | Not serious | Not serious | Not serious | Strong association | 20/392 (5.1%) | 24/168 (14.3%) | OR 2.56 (1.16 to 5.67) | 156 more per 1000 (from 19 more to 343 more) | ⨁⨁⨁◯Moderate | SIGNIFICANT, CRITICAL |
CI: confidence interval; OR: odds ratio.