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. 2022 Dec 7;13(12):2309. doi: 10.3390/genes13122309

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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PPI network of the STRING tools among the proteins encoded by 15 EMT genes and divided into four distinct groups. The combined interaction score of p > 0.9 was considered significant. (A) PPI network of the 15 EMT genes (MMP3, ITGAV, KRT14, PLEK2, SNAI2, GSK3B, ITGB1, MAP1B, TCF3, VPS13A, SMAD2, MMP2, SPARC, WNT5A, and ITGA5) (B) PPI network of the AC vs. TC (MMP3 and SNAI2); (C) PPI network of the LCNEC vs. AC (MMP3, ITGAV, KRT14, PLEK2, and SNAI2); (D) PPI network of the SCLC vs. AC (PLEK2, MAP1B, MMP2, SNAI2, SPARC, WNT5A, and ITGA5); (E) PPI network of the SCLC vs. LCNEC (GSK3B, ITGB1, MAP1B, TCF3, VPS13A, and SMAD2).