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. 2022 Dec 18;11(24):4094. doi: 10.3390/foods11244094

Table 2.

Top 10 most cited articles in the whole grain health effect research.

Ranking Title Issue Journal Citations Year
1st Health effects of dietary risks in 195 countries, 1990–2017: a systematic analysis for the global burden of disease study 2017 This study evaluated the impact of dietary risk factors on the mortality rate of non-communicable diseases, including high sodium, low whole grain, low fruit intake. The Lancet 1607 2019
2nd Fiber and prebiotics: mechanisms and health benefits This review summarizes the benefits of dietary fiber as prebiotics to promote the reproduction of gastrointestinal probiotics and maintain human health. Nutrients 999 2013
3rd Whole grain consumption and risk of cardiovascular disease, cancer, and all-cause and cause-specific mortality: systematic review and dose-response meta-analysis of prospective studies This meta-analysis demonstrates that whole grain intake is associated with reduced risk of coronary heart disease, cardiovascular disease and total cancer and all-cause mortality. BMJ-British Medical Journal 538 2016
4th Carbohydrate quality and human health: a series of systematic reviews and meta-analyses Prospective studies and clinical trials have found that relatively high dietary fiber and whole grain intakes reduce all-cause and cardiovascular-related mortality, the incidence of type 2 diabetes and colorectal cancer, body weight, systolic blood pressure and total cholesterol, and there is dose-response evidence. The relationship with several non-communicable diseases may be causal. The Lancet 533 2019
5th Greater whole grain intake is associated with lower risk of type 2 diabetes, cardiovascular disease, and weight gain This meta-analysis shows that whole grain and high fiber intake can prevent vascular disease and reduce the risk of type 2 diabetes and weight gain. Journal of Nutrition 485 2012
6th Gut microbiome composition is linked to whole grain-induced immunological improvements This study shows that short-term intake of whole grains can cause changes in intestinal microflora. Whole wheat barley and brown rice increase the abundance of probiotics and improve immune response. ISME Journal 343 2013
7th Whole grain and refined grain consumption and the risk of type 2 diabetes: a systematic review and dose-response meta-analysis of cohort studies This systematic review and dose-response meta-analysis showed that whole wheat bread, whole wheat cereals, wheat bran, and brown rice were negatively associated with type 2 diabetes, and white rice increased the risk of diabetes. European Journal of Epidemiology 329 2013
8th Nutrients, foods, and colorectal cancer prevention This review focuses on diets to prevent colorectal cancer caused by immune reactivity and risk factors for inflammation, overnutrition, and obesity. Calcium, fiber, milk, and whole grains reduce colorectal cancer risk. Gastroenterology 315 2015
9th A prospective study of long-term intake of dietary fiber and risk of Crohn’s disease and ulcerative colitis Long-term intake of dietary fiber, particularly fruit fiber, is associated with a lower risk of Crohn’s disease, but not ulcerative colitis. Fiber from grains, whole grains or legumes does not change disease risk. Gastroenterology 304 2013
10th Adherence to Mediterranean diet and risk of cancer: an updated systematic review and meta-analysis In this systematic review and meta-analysis, reduced risk of cancer death appears to be most attributable to fruits, vegetables and whole grains, especially colorectal cancer. Nutrients 299 2017