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. 2022 Dec 16;13(12):2392. doi: 10.3390/genes13122392

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Pedigree of the multiplex MS family and segregation of GRAMD1B c.1801T > C (p.S601P) variant. Squares represent men, circles represent women; slash, deceased subjects; black-filled symbols represent individuals diagnosed with MS. The first-cousin marriage between two unaffected individuals, subject I-1 and subject I-2, is indicated by a double line. +/+: homozygous individuals for mutated allele; −/−: homozygous individuals for wild-type allele; +/−: heterozygous individuals. The numbers reported inside circles and squares indicate age at sampling of the subject. The smaller arrowhead represents the proband; larger thick arrows represent samples subjected to whole-genome sequencing.