Table 2.

Human Neuraminidases (NEUs). Information regarding alternative names, substrate carrier, intracellular localization, etc., corresponding to NEUs can be found in the table below.

Enzymes	Other Names	Substrate Carrier	Tissue Expression	Intracellular Localization	Glycosidic Linkage Specificity
NEU1	Lysosomal sialidase, SIAL1	OL, glycopeptides	Kidney, pancreas, skeletal muscle, liver, lungs, placenta, and brain	Lysosomal and plasma membranes	α2-3 faster than α2-6 and α2-8 [10]
NEU2	Cytosolic sialidase, SIAL2	OL, GP, GL	Skin	Cytosol	α2-3 faster than α2-6 and α2-8 [10]
NEU3	Membrane sialidase, SIAL3	GL, Grb2	Adrenal gland, skeletal muscle, heart, testis, and thymus	Caveolae microdomains of plasma, endosomal and lysosomal membranes	α2-3 and α2-8 almost equally and faster than α2-6 [11]
NEU4	Sialidase	OL, GP, GL, phospholipid scramblase 1	Brain, skeletal muscle, heart, placenta, and liver	ER membrane, mitochondria, and lysosomes	-

GP = glycoproteins, GL = gangliosides, Grb2 = growth factor receptor bound protein 2.