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. 2022 Dec 2;13(12):2276. doi: 10.3390/genes13122276

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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ScRNA-seq revealed heterogeneity in T immune cells. (a,b) T-SNE map of subcluster analysis for T immune cells, colored by cell types (a) and sample groups (b). (c) T-SNE maps show canonical markers for four T immune cell subtypes: GZMA for CD8⁺ T effector cells; CD8A for CD8⁺ T naïve cells; CCR7 for CD4⁺ T conventional cells; FOXP3 for CD4⁺ CD25⁺ T regulatory cells. (d) Functional analysis of differentially expressed genes among four subtypes of T cells. (e) Expression levels of other representative marker genes for CD4⁺ CD25⁺ T regulatory cells. (f) Dendritic cells highly expressed the IDO-related genes. (g) Tryptophan metabolism pathway-related genes were highly expressed in Treg cells.