Table 5.

Comparison of linear regression models for peak and trough enalaprilat concentrations, using CES1A2 or rs2244613 as predictors.

Model	R2	Adjusted R2	R2 Change	p
Peak enalaprilat concentration
H0 (age, sex, dose(ln), CES1Ac)	0.359	0.348	0.359	<0.001
Adding CES1A2 to H0	0.386	0.37	0.027	0.003
Adding CES1 rs2244613 to H0	0.383	0.368	0.024	0.004
Trough enalaprilat concentration
H0 (age, dose(ln), CES1Ac)	0.285	0.274	0.285	<0.001
Adding CES1A2 to H0	0.31	0.294	0.025	0.01
Adding CES1 rs2244613 to H0	0.312	0.296	0.026	0.008