Table 3. Interactions with MHC risk variation.
| Global Interaction | Local Interaction | Sex Interaction | ||||||
|---|---|---|---|---|---|---|---|---|
| Alleles/SNPs | Pos Hg19 (MB) | Population | HISP P | AA P | HISP P | AA P | HISP P | AA P |
| A*02:01 | HISP + AA | 2.23E-01 | 7.92E-01 | 1.40E-01 | 4.14E-02 | 8.15E-01 | 2.33E-02 | |
| B*53:01‡ | AA | 4.14E-01 | 6.68E-01 | 4.37E-02 | 7.02E-02 | 6.51E-01 | 3.80E-01 | |
| DRB1*13:03 | HISP | 1.82E-01 | 1.84E-01 | 3.04E-01 | 5.35E-01 | 3.60E-01 | 6.87E-01 | |
| DRB1*15:01 | HISP + AA | 9.68E-01 | 3.42E-01 | 3.47E-01 | 5.09E-02 | 3.44E-01 | 1.53E-01 | |
| DQB1*02:01 | HISP | 6.17E-01 | 4.49E-01 | 8.62E-01 | 2.89E-01 | 1.85E-02 | 1.99E-01 | |
| DQB1*06:02 | HISP | 1.71E-01 | 1.02E-01 | 4.33E-02 | 9.62E-03 | 8.35E-01 | 1.62E-01 | |
| DPB1*03:01 | HISP | 6.62E-01 | 2.65E-01 | 2.08E-01 | 2.00E-01 | 8.23E-01 | 9.60E-01 | |
| rs6929950† | 29.4 | HISP | 6.44E-01 | 4.87E-01 | 2.01E-01 | 2.72E-02 | 1.98E-01 | 2.76E-01 |
| rs760145‡ | 29.7 | AA | 2.73E-01 | 1.45E-03 | 2.13E-01 | 2.60E-01 | 8.49E-01 | 4.79E-01 |
| rs6902067 | 31.4 | HISP | 6.43E-01 | 7.29E-01 | 6.42E-01 | 2.23E-01 | 1.28E-01 | 2.66E-01 |
| rs2844503 | 31.4 | HISP | 4.66E-04 | 9.03E-01 | 2.83E-01 | 2.32E-01 | 4.10E-01 | 2.13E-01 |
| rs2516423 | 31.4 | AA | 3.37E-01 | 6.59E-01 | 5.09E-01 | 9.11E-01 | 3.11E-01 | 2.11E-02 |
| rs371143509 | 31.5 | HISP | 2.43E-01 | 7.35E-01 | 8.40E-01 | 4.29E-01 | 1.81E-01 | 4.10E-01 |
| rs3021302 | 32.6 | HISP | 2.95E-02 | 3.86E-01 | 2.76E-02 | 3.10E-01 | 5.86E-01 | 4.50E-01 |
| rs28371315 | 32.7 | AA | 3.05E-01 | 8.69E-01 | 1.11E-01 | 2.10E-01 | 8.20E-01 | 1.84E-01 |
| rs112394499 | 33.1 | HISP | 4.07E-01 | 6.14E-01 | 1.05E-01 | 2.17E-01 | 6.13E-01 | 6.18E-01 |
Population indicates the sample in which the variant was identified.
‡ indicates a novel variant in African Americans † indicates a novel variant in Hispanics.
Bold indicates p ≤ 0.05.