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Metformin reduces HA production. (a) TAO-OFs were pretreated with metformin for 24 h and then stimulated with 1 ng/mL IL-1β for 24 h. The ELISA results show the changes in the HA levels after stimulation and treatment. (b,c) Quantitative analysis of HAS1 and HAS2 mRNA levels. n = 3 in each group. #### p ≤ 0.0001, compared with the control group, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001, compared with the IL-1β group. (ANOVA).
