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. 2022 Dec 11;23(24):15705. doi: 10.3390/ijms232415705

Figure 1.

Figure 1

Down-regulation of TRIB3 in IPF lung. (A) TRIB3 was down-regulated in IPF patients, which was profoundly validated from the Gene Expression Omnibus (GEO) RNA-seq dataset (GSE32537). Statistical analysis of the microarray was performed by R package “limma”. (B) TRIB3 was negatively correlated with COL1A1, COL1A2, FN1, and ACTA2. Data were obtained from GSE32537 (Control = 50, IPF = 119) in the public database Gene Expression Omnibus (GEO). Spearson rank analysis was used to analyze the correlation between TRIB3 and FN1, ACTA2, COL1A1, and COL1A2 expression. (C) TRIB3 was down-regulated from patients with IPF in transcription level. The statistical test used was the Mann–Whitney U test for comparisons between two groups. * p < 0.05. (D) Western blot analysis showed reduced TRIB3 expression in IPF lungs (N = 4) compared with healthy lungs (N = 4). The statistical test used was the Mann–Whitney U test for comparisons between two groups. * p < 0.05.