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. 2022 Dec 9;23(24):15604. doi: 10.3390/ijms232415604

Figure 1.

Figure 1

Overview of the ONH and contributory vascular components, and limitations of vascular leakage in rNAION. (A). Schematic of the vascular supply of the primate ONH, The ONH is partially bounded by the thick scleral wall, which resists lateral expansion. The fenestrated lamina within the ONH enables transit of the RGC axons. ONH circulation is a plexus formed with contributions from intraretinal, choroidal, optic nerve intraneural and pial circulations, as well as direct contribution from the short posterior ciliary arteries (SPCAs) in primates. (B). H&E-stained cross-section of the rat ONH. The unmyelinated portion of the ONH is bounded by the sclera, and smaller in diameter than the myelinated distal ON. The arrowheads above the figure indicate 500 µm boundary. (C). Limits of ONH vascular leakage following rNAION induction (arrow) 1d post-induction in the rNAION model. Immunohistochemistry using labeled 3 kDa (red-Dextran) and 55 kDa (green-FITC/BSA) probes. Serum leaks from decompensated capillaries in the ONH in a focal manner, with distal ON vasculature unimpaired. Scale bar: 100 µm in (B,C).