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. 2022 Dec 9;23(24):15604. doi: 10.3390/ijms232415604

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of an astrocytic TRPM4/SUR1 (white matter edema inhibitor) on ONH edema and RGC survival post-rNAION. Adult rats were administered glibenclamide (40 ug/kg) immediately after rNAION induction and daily for 4 subsequent days via intraperitoneal injection. (A). ONH edema 2d post-induction. Minimal reduction was seen in glibenclamide-treated animals (ONH mean values 516 ± 17µm in vehicle-treated vs. 492 ± 20µm s.e.m in glibenclamide-treated animals; n = 4). (B). RGC survival post-rNAION induction. Brn3a(+)-RGC counts in naïve retinae yielded a ratio of 1423.2 ± 19.3 cells/unit area (n = 10 animals). Retinae 30d post-induction yielded a mean of 767.6 ± 167.6 cells/unit area for vehicle treatment vs. 775.7 ± 149.1 cells/unit area for glibenclamide treatment.