Table 1.

Rate constant for the hydrolysis of nucleotides under acidic, neutral and alkaline conditions.

Substrate	Conditions	k/10−6 s−1
5′-dTSMP (4a)	pH 3, 298 K	152
	pH 7, 298 K	5.19
	pH 7, 308 K	17.1
	pH 7, 318 K	58.4
	pH 11, 298 K	0.34
5′-dTSeMP (4b)	pH 3, 298 K	53.1
	pH 7, 298 K	16.8
	pH 7, 303 K	75.1
	pH 7, 313 K	297
	pH 11, 298 K	14.4
5′-TMP (4c)	pH 3, 363 K	2.60