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. 2022 Dec 10;23(24):15675. doi: 10.3390/ijms232415675

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The role of NCS-1 in hyperexcitation of non-GABAergic (GAD65/67^–) and GABAergic neurons of the cerebral cortex under the action of hyperammonemia. NCS-1 contributions to NH₄Cl-induced global [Ca²⁺]_i increase in GABAergic neurons. (A, B) Ca²⁺-signals of control (Scra) non-GABAergic (GAD65/67^–) (A) and GAMBergic (B) neurons of the cerebral cortex upon application of 8 mM NH₄Cl. (C, D) Ca²⁺-signals of non-GABAergic (C) and GABAergic (D) neurons of the cerebral cortex after NCS-1-KD upon application of 8 mM NH₄Cl. Typical Ca²⁺-signals of neurons in one experiment are shown.