Table 1.
Parameters of twitch and tetanus in EDL and SOL muscles.
| EDL | SOL | |||||||
|---|---|---|---|---|---|---|---|---|
| Twitch | Tetanus | Twitch | Tetanus | |||||
| Cre−/− | Cre+/− | Cre−/− | Cre+/− | Cre−/− | Cre+/− | Cre−/− | Cre+/− | |
| Number of muscles | 26 | 22 | 26 | 22 | 25 | 22 | 25 | 22 |
| Peak force (mN) | 1.53 ± 0.09 | 0.80 ± 0.10 *** | 8.08 ± 0.43 | 3.49 ± 0.42 *** | 1.83 ± 0.12 | 0.57 ± 0.13 *** | 9.41 ± 0.49 | 4.09 ± 0.69 *** |
| Force (mN/mm2) | 1.49 ± 0.12 | 1.29 ± 0.21 | 7.84 ± 0.52 | 5.61 ± 0.91 * | 2.60 ± 0.22 | 0.81 ± 0.22 *** | 13.38 ± 1.16 | 5.09 ± 0.94 *** |
| TTP (ms) | 37.1 ± 2.8 | 40.8 ± 1.8 | 209.9 ± 12.9 | 147.8 ± 13.4 ** | 109.1 ± 7.2 | 88.9 ± 4.2 * | 517.3 ± 12.7 | 526.0 ± 2.6 |
| HRT (ms) | 32.5 ± 2.7 | 33.1 ± 1.3 | 69.2 ± 3.7 | 118.8 ± 11.1 *** | 102.7 ± 10.9 | 110.6 ± 8.5 | 142.5 ± 5.9 | 98.9 ± 3.2 *** |
| Duration (ms) | 246.1 ± 30.5 | 233.1 ± 14.4 | 376.4 ± 18.0 | 376.9 ± 14.2 | 401.2 ± 35.2 | 479.9 ± 46.4 | 834.0 ± 29.0 | 764.5 ± 13.6 * |
| Fatigue at 50th (%) | 34.4 ± 2.3 | 52.0 ± 4.9 ** | 41.8 ± 2.6 | 48.6 ± 3.2 | ||||
| Fatigue at 100th (%) | 60.9 ± 2.6 | 65.7 ± 5.4 | 59.5 ± 2.3 | 64.1 ± 3.3 | ||||
| Fatigue at 150th (%) | 70.8 ± 2.5 | 71.0 ± 5.1 | 65.4 ± 2.2 | 69.7 ± 3.5 | ||||
| CSA (mm2) | 1.07 ± 0.04 | 0.81 ± 0.06 ** | 0.80 ± 0.06 | 0.96 ± 0.07 | ||||
| Muscle weight (mg) | 12.8 ± 0.4 | 11.5 ± 0.3 * | 11.0 ± 0.6 | 14.3 ± 0.5 *** | ||||
*, ** and ***: significant difference from CRE- at p < 0.05, p < 0.01 and p < 0.001, respectively. TTP: time to peak; HRT: half relaxation time; CSA: cross sectional area.