Table 1.

Clinical Findings in Patients with Reported Medich Syndrome. + OCP; oral contraceptives; ++ CHD: congenital heart disease; +++ EGA; estimated gestational age.

Patient	Sex	Ethnicity	Age of Initial Thrombocytopenia	Age at Diagnosis	Bleeding Symptoms	Therapies	Other Findings	Ref.
1	Female	Hispanic	2 weeks	8 years	Bruising Mucosal bleeding	IVIG Steroids Anti-CD20 Immunosuppressants Platelet transfusion Splenectomy Antifibrinolytics OCP+	Duplication of alpha     globin gene in one     allele Missense in the SLFN14     gene, c.652A > G
2	Male	African American	Birth	6 years	Bruising Oral mucosal bleeding	Platelet transfusion Antifibrinolytics	Maternal     thrombocytopenia
3	Female	Caucasian	1 year	19 years	Bruising Bleeding with piercings     and dental work Menorrhagia	Platelet transfusion Splenectomy OCP+ Antifibrinolytics	None	[14]
4	Male	Caucasian	Birth	2 years		Platelet transfusion	CHD++ Craniosynostosis 4Ydel (11q23.3)	[15]
5	Female	Caucasian	Birth	18 months	Subdural hematoma	Platelet transfusion	EGA+++ 29 weeks     one of fraternal     triplets	[15]