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. 2022 Dec 12;23(24):15759. doi: 10.3390/ijms232415759

Table 2.

Crosstalk between different methylation types and lncRNAs in BC.

LncRNAs Epigenetic Mechanism Expression in BC Target Gene or Protein/Pathway Involved Biological Function Ref.
LncRNA APOC1P1-3 Regulation of lncRNA expression by DNA methylation APOC1P1-3/α-tubulin acetylation Inhibiting apoptosis [75]
LncRNA EPIC1 LncRNA EPIC1/MYC Promoting Cell-Cycle progression [76]
LncRNA HUMT HUMT/YBX1/FOXK1 axis Promoting lymphangiogenesis and metastasis [77]
LncRNA GAS5 Not applicable Promoting chemosensitivity and apoptosis [78]
LncRNA MEG3 Not applicable Promoting chemosensitivity [79]
LncRNA MYMA Regulation of DNA methylation by lncRNA ROR1/HER3/lncRNA MYMA axis Promoting bone metastasis [80]
LncRNA 91H LncRNA 91H -H19/IGF2 Increasing aggressive phenotype [81]
LncRNA PYCARD-AS1 Not applicable LncRNA PYCARD-AS1/PYCARD Regulating apoptosis [82]
LINC00518 LINC00518/CDX2/Wnt signaling Promoting epithelial cell growth and metastasis [83]
LncRNA H19 H19/SAHH/DNMT3B axis Promoting tamoxifen resistance [84]
LncRNA BCLIN25 BCLIN25/miR-125b/ERBB2 axis Promoting tumorigenesis [85]
LncRNA MIAT LncRNA MIAT/DLG3/Hippo signaling pathway Promoting tumorigenesis [86]
LINC00472 LINC00472/MCM6/MEK/ERK signaling pathway Inhibiting metastasis [87]
LncRNA TINCR STAT3/TINCR/EGFR feedback loop Promoting tumorigenesis [88]
LncRNA LINC00922 LINC00922/NKD2/Wnt signaling pathway Promoting EMT, invasive and migratory capacities [89]
LncRNA MAGI2-AS3 MAGI2-AS3/MAGI2/Wnt/β-catenin pathway Inhibiting cell proliferation and migration [90]
LncRNA SNHG10 LncRNA SNHG10/miR-302b Promoting chemosensitivity of TNBC cells to doxorubicin. [91]
LNC942 Regulation of m6A modification by lncRNA LNC942/METTL14/CXCR4 and CYP1B1 signaling axis Promoting proliferation and inhibiting apoptosis [92]
LINC00675 M6A modification of lncRNA METTL3/LINC00675/miR-513b-5p Suppressing proliferation, migration, and invasion [93]
LncRNA DLEU1 Regulation of lncRNA expression by histone methylation Not applicable Promoting tumorigenesis [94]
LncRNA EPB41L4A-AS2 ZNF217/EPB41L4A-AS2/RARRES1 Inhibiting proliferation, migration, and invasion and inducing apoptosis [95]
LncRNA HOTAIR Not applicable Associating with endocrine disruption [96]
LncRNA UCA1 Not applicable SATB1/lncRNA UCA1 Promoting growth and metastasis [97]
LncRNA HOTAIR Regulation of histone methylation by lncRNA Not applicable Promoting invasiveness and metastasis [98]
LncRNA UCA1 LncRNA UCA1/EZH2/p21 axis Inducing tamoxifen resistance [99]
LINC00511 LINC00511/EZH2/CDKN1B Promoting proliferation and inhibiting apoptosis [100]
LncRNA ROR LncRNA ROR/MLL1/TIMP3 Promoting BC progression [101]
LncRNA PHACTR2-AS1 EZH2/lncRNA PHACTR2-AS1 Inhibiting growth and metastasis [102]

EMT, epithelial–mesenchymal transition. ↓, down-regulation in BC. ↑, up-regulation in BC.