2K1C |
two-kidney: one-clip (2K1C) Goldblatt hypertension |
ACE |
angiotensin-converting enzyme |
Agtr1a
−/−
|
mutant mice with whole-body deletion of the angiotensin II AT1a receptor |
Ang I |
angiotensin I |
Ang II |
angiotensin II |
AT1 (AT1a) |
type 1 (1a) receptor for Ang II |
GFR |
glomerular filtration rate |
iL-Sglt2-Cre
|
mutant mice with tissue-specific expression of Cre recombinase selectively in the proximal tubules of the kidney driven by the sodium and glucose cotransporter 2 (Sglt2) promoter |
NHE3 |
the Na+/H+ exchanger 3 |
PT-Agtr1a−/−
|
mutant mice with genetic deletion of AT1 (AT1a) receptors selectively in the proximal tubules of the kidney |
PT-Nhe3−/−
|
mutant mice with genetic deletion of the Na+/H+ exchanger 3 (NHE3) selectively in the proximal tubules of the kidney |
RAS |
the renin-angiotensin system |
WT |
wild-type mice |