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. 2022 Dec 7;23(24):15462. doi: 10.3390/ijms232415462

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Chronic intermittent hypoxia leads to global transcriptomic changes in BAT. (A) Example of pathways up/downregulated in IH-exposed BAT. (B) The most altered pathways between IH and room air-exposed BAT. (C) Expression of selected genes in signaling pathways relevant to brown adipose tissue (left to right): lipid droplet structure (Cidec, Lpl, Slc4a4, Cldn1), myogenesis (obscn, myl3, myh7), thermogenesis (UCP1, Dio2), angiogenesis (Vegfa, Pecam1, PGC1a), and glucose utilization (Glut4).