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. 2022 Dec 12;23(24):15742. doi: 10.3390/ijms232415742

Figure 1.

Figure 1

SacsJ disassembled NFL filaments in vitro. Shown are representative TEM images of filaments assembled from purified NFL (A). Assembled NFL filaments were incubated with or without SacsJ for 1 h at 37 °C and observed by TEM. Representative TEM images of filamentous NFL (A), SacsJ alone (B) or filamentous NFL co-incubated with SacsJ at a molar ratio of 1:5 (C). Inserts show enlargements of TEM images focused on NFL filaments (arrow). Scale Bar: 40 nm. Quantitation of NFL average length (D) and filament density (E) with or without incubation with SacsJ shows the significant decrease in NFL length and density (filaments/µm2). * p < 0.05 vs. NFL alone; one-way ANOVA, HSD Tuckey post hoc analysis (n = 3).

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