Skip to main content
. 2022 Dec 13;23(24):15779. doi: 10.3390/ijms232415779

Figure 1.

Figure 1

Multidrug efflux pumps in P. aeruginosa. (a) Schematic structures of the four main efflux pumps involved in antibiotic resistance in P. aeruginosa, showing the resistance-nodulation-cell division transporters (MexB, MexY, MexD and MexF) on the inner membrane; the periplasmic membrane fusion proteins (MexA, MexX, MexC and MexE) on the periplasm; and the channel-forming outer membrane factors (OprM, OprJ and OprN) on the outer membrane. Protein representations based on the Protein Databank (PDB) structures: 2V50, 4DK1 and 3D5K. (b) Organization of the Mex operons and upstream regulatory genes in the P. aeruginosa genome. Regulatory genes are represented in white, and the Mex coding sequences follow the same color patterns of the protein structures shown in (a). Created with BioRender.com.