Figure 3.

Schematic illustration of PyK2-associated molecules. Various molecules affect PyK2 activation, including chemical reagents, interactive proteins, chemokine-related molecules, Ca²⁺ channels, transporters, and oxidation-mediated molecules. The phosphorylation of PyK2 induces cancer cell migration and proliferation. Various effector signals and chemicals exert different phosphorylation effects on PyK2. Thus, verification of the phosphorylation status of PyK2 could be a prognostic marker for evaluating cancer progression.