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. 2022 Dec 12;23(24):15765. doi: 10.3390/ijms232415765
PTOX Podophyllotoxin
CPT Camptothecin
ROS Reactive oxygen species
IL-1 Interleukin 1
TNF-α Tumor necrosis factor
NO Nitric oxide
EGCG Epigallocatechin gallate
NSCLC Non-small-cell lung carcinoma
PKC Protein kinase C
FDA US Food and Drug Administration
MAPs Microtubule associated proteins
MIPs Microtubule interacting proteins
PTMs Post translational modifications
STAT3 Signal Transducers and Activators of Transcription-3
VEGF Vascular endothelial growth factor
UCP-2 Uncoupling protein 2
TLR-4 Toll like receptor 4
JNK/SAPK c-Jun N-terminal kinase/stress-activated protein kinase
EPC Endothelial progenitor cells
MAPKs Mitogen-activated protein kinases
TME Tumor microenvironment
ERK1/2 Extracellular signal-regulated protein kinase
NPs Nanoparticles
CPT-11,4 Irinotecan
CKD-602,5 Belotecan
HCPT 10-hydroxycamptothecin
DMEP 4’-demethylepipodophyllotoxin
PPP Picropodophyllotoxin
IGF-1R Insulin-like growth factor-1 receptor
IR Insulin receptor
pErk1/2 Phosphorylated extracellular signal-regulated kinases 1 and 2
IM Ingenol mebutate
HHT Homoharringtonine
CMML Myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia
EGF Epidermal growth factor
FOXO3a Fork head box O3a
GSK3 Glycogen synthase kinase 3
HUVECs Human umbilical vein endothelial cells
CDC The Centers for Disease Control and Prevention
CXCL-1,2 C-X-C motif ligands 1 and 2