Figure 1.

Inhibition of cholesterol synthesis pathway by bempedoic acid and statins. Bempedoic acid inhibits ACL upstream of HMG CoA reductase (top of figure). Statins inhibit HMG CoA reductase downstream of ACL (center of figure). BA and statins promote the upregulation of LDL receptors thereby increasing LDL-C clearance and reducing plasma LDL-C (bottom of figure). ACL, ATP citrate lyase; BAA, bempedoic acid; HMG-CoA, β-hydroxy β-methylglutaryl-CoA; LDL-C, low-density lipoprotein cholesterol; LDL-R, low-density lipoprotein receptor.