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Regulation of miR-10a expression. (A) miR-10a induction. Transcription factors p65 and TWIST1 bind to the promoter region of the miR-10a gene resulting in the induction of miR-10a expression. (B) miR-10a suppression. DNA methyltransferases DNMT1 and DNMT3b cause promoter methylation of the miR-10a gene resulting in the down-regulation of miR-10a expression.
