Table 2.
Summary statistics of significant SNP associations with psychological parameters and with frailty.
|
SF-36-PCS
SNP |
Risk Allele | Genotype | Mean (st dev) | Comparison a | Beta | 95% CI | p Value | |
|
CNTF rs1800169 [G>A] |
G | AA AG GG |
46.6 (8.3) 47.5 (8.5) 46.1 (8.5) |
GG vs. AG/AA | −1.33 | [−2.36;−0.30] | 0.007 | |
|
TGFB1 rs1800469 [C>T] |
C | CC CT TT |
45.7 (8.5) 47.3 (8.4) 46.6 (8.5) |
CC vs. TC/TT | −1.38 | [−2.36;−0.40] | 0.010 | |
|
MTR rs1050993 [G>A] |
G | AA AG GG |
47.5 (8.9) 46.3 (8.4) 46.1 (8.3) |
AG/GG vs. AA | −1.29 | [−2.46;−0.13] | 0.019 | |
|
MMSE
SNP |
Risk Allele | Genotype | % MMSE < 24 | Comparison b | OR | 95% CI | p Value | |
|
IL6 rs1800795 [G>C] |
G | CC CG GG |
7 3.4 8.9 |
CG/GG vs. CC | 2.26 | [1.37;3.79] | 0.0016 | |
|
Frailty
SNP |
Risk Allele | Genotype | % Pre-Frailty | % Frailty | Comparison c | OR | 95% CI | p Value |
|
FN1 rs7567647 [G>A] |
A | AA AG GG |
23.1 34.6 39.6 |
61.5 33.8 34.4 |
AA vs. AG AA vs. GG |
3.85 3.45 |
[1.92;8.33] [1.75;7.69] |
0.0003 0.0006 |
a Linear regression model with covariates weight groups, daily drugs, presence of caregiver, school years and annual outcome. b Logistic regression model with covariates sex, weight groups, daily drugs, presence of caregiver, leisure activities and annual outcome. c Nominal model with covariates sex, age groups, weight groups, daily drugs, presence of caregiver, school years, leisure activities and annual outcome. p values are relative to normalized values.