Table 3.
Summary of completed clinical studies concerning spine tumors. Information retrieved from ClinicalTrials.gov using the following search constraints: “Spine tumor”—with results.
| ClinicalTrials.gov Identifier | Official Title | Intervention/Treatment | Phase | Actual Study Completion Date | Reference |
|---|---|---|---|---|---|
| NCT00593320 | Stereotactic Radiosurgery (SRS) for One or Two Localized Spine Metastases | Radiation: Stereotactic Radiosurgery | Not Applicable | March 2010 | [96] |
| NCT01525745 | Randomized Ph II Study of Stereotactic Body Radiotherapy (SBRT) Versus Conventional Radiation for Spine Metastasis | Radiation: Radiosurgery/SBRT Radiation: External Beam Radiation Therapy |
Phase 2 | January 2014 | [97] |
| NCT03050203 | Surgical Field Custom Pack’s Efficacy on Soft Tissue Dissecting Time Reduction, on Relative Risks and Materials Wasted, in Patients Undergoing Spine Surgery: Randomized Controlled Trial | Other: custom pack Other: standard care |
Not Applicable | 30 July 2016 | [98] |
| NCT01654068 | Conformal High Dose Intensity Modulated Radiation Therapy for Asymptomatic Metastatic Disease to the Thoracic and Lumbar Spine | Radiation: Conformal High Dose Intensity Modulated Radiation Therapy | Not Applicable | 8 September 2016 | [99] |
| NCT01757717 | A Pilot Study of Image-Guided Navigation for High Dose Rate Temporary Interstitial Brachytherapy in the Palliative Management of Previously Treated Tumors of the Spine and Pelvis | Radiation: Ir-192 high dose rate (HDR) | Not Applicable | July 2017 | [100] |
| NCT01347307 | Phase IV Trial Evaluating the Use of Stereotactic Body Radiotherapy for the Treatment of Spine Metastases and Primary Spine Tumors | Radiation: SBRT for Benign Extradural Spine Tumors Radiation: SBRT for Vertebral/Paraspinal Metastases | Not Applicable | September 2017 | [101] |
| NCT01752036 | Phase II Study of Postoperative Stereotactic Radiosurgery for Solid Tumor Spine Metastases | Radiation: Postoperative, SBRT | Phase 2 | 27 July 2018 | [102] |
| NCT00922974 | Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis | Radiation: External beam radiation therapy Radiation: Radiosurgery/SBRT |
Phase 2 Phase 3 |
6 April 2020 | [103] |
| NCT03249584 | OsteoCool Tumor Ablation Post-Market Study (OPuS One) | Device: OsteoCool™ RF Ablation | Not Applicable | 17 July 2020 | [104] |
| NCT00855803 | Phase II Study of Stereotactic Body Radiation Therapy and Vertebroplasty for Localized Spinal Metastasis (SBRT Spine) | Radiation: radiation | Phase 2 | 20 January 2021 | [105] |
| NCT02085941 | Image-guided Cryoablation of Head, Neck and Spine Tumors | Device: Cryoablation Device: Biopsy |
Not Applicable | July 2021 | [106] |
Abbreviations: SBRT—stereotactic body radiotherapy; RF—radiofrequency.