Table 2.
MEL and GC levels before and after thrombolysis, considering the mRS scale.
| Biomarkers | Favourable (mRS 0–2 pts) (N = 26) |
Unfavourable (mRS 3–6 pts) (N = 96) |
p-Value | |
|---|---|---|---|---|
| CG (0) Median [Q1, Q3] [U/mL] | on admission | 180.58 [118.95, 219.67] | 255.15 [183.21, 294.12] | 0.002 |
| CG (1) Median [Q1, Q3] [U/mL] | 280.69 [259.41, 384.24] | 373.60 [223.59, 476.17] | 0.240 | |
| CG (2) Median [Q1, Q3] [U/mL] | 179.26 [98.86, 251.32] | 195.09 [137.31, 235.68] | 0.843 | |
| MEL (0) Median [Q1, Q3] [pg/mL] | 6.87 [4.95, 13.60] | 6.31 [3.98, 7.90] | 0.175 | |
| MEL (1) Median [Q1, Q3] [pg/mL] | 31.00 [8.66, 36.60] | 8.02 [4.68, 19.10] | 0.010 | |
| MEL (2) Median [Q1, Q3] [pg/mL] | 16.90 [3.39, 23.40] | 9.38 [6.56, 13.20] | 0.982 | |
| (N = 90) | (N = 29) | |||
| CG (0) Median [Q1, Q3] [U/mL] | on discharge | 202.85 [157.72, 267.31] | 274.65 [234.80, 301.28] | 0.007 |
| CG (1) Median [Q1, Q3] [U/mL] | 347.40 [250.80, 427.91] | 405.83 [219.42, 492.35] | 0.689 | |
| CG (2) Median [Q1, Q3] [U/mL] | 195.35 [119.77, 246.80] | 194.82 [137.73, 233.70] | 1 | |
| MEL (0) Median [Q1, Q3] [pg/mL] | 6.04 [4.19, 9.41] | 6.62 [5.46, 8.20] | 0.835 | |
| MEL (1) Median [Q1, Q3] [pg/mL] | 8.66 [4.98, 29.60] | 13.50 [8.29, 21.30] | 0.495 | |
| MEL (2) Median [Q1, Q3] [pg/mL] | 12.50 [6.14, 23.40] | 8.32 [5.98, 10.30] | 0.255 | |
| (N = 84) | (N = 27) | |||
| CG (0) Median [Q1, Q3] [U/mL] | after three months | 203.23 [164.19, 274.65] | 259.63 [230.33, 306.63] | 0.012 |
| CG (1) Median [Q1, Q3] [U/mL] | 347.40 [250.80, 427.91] | 438.31 [307.31, 696.33] | 0.296 | |
| CG (2) Median [Q1, Q3] [U/mL] | 169.07 [119.37, 235.57] | 214.41 [153.92, 239.03] | 0.566 | |
| MEL (0) Median [Q1, Q3] [pg/mL] | 6.38 [3.99, 9.84] | 5.93 [4.43, 8.20] | 0.940 | |
| MEL (1) Median [Q1, Q3] [pg/mL] | 8.66 [4.72, 28.10] | 8.80 [6.83, 15.90] | 0.962 | |
| MEL (2) Median [Q1, Q3] [pg/mL] | 10.80 [4.73, 17.60] | 9.15 [6.96, 9.62] | 0.607 | |
| (N = 78) | (N = 17) | |||
| CG (0) Median [Q1, Q3] [U/mL] | after a year | 197.85 [157.72, 258.25] | 291.47 [244.18, 361.20] | 0.005 |
| CG (1) Median [Q1, Q3] [U/mL] | 307.53 [222.20, 429.44] | 621.15 [421.70, 797.09] | 0.111 | |
| CG (2) Median [Q1, Q3] [U/mL] | 149.94 [113.17, 224.83] | 194.82 [140.29, 234.00] | 0.679 | |
| MEL (0) Median [Q1, Q3] [pg/mL] | 6.38 [3.99, 9.84] | 6.85 [5.58, 8.49] | 0.557 | |
| MEL (1) Median [Q1, Q3] [pg/mL] | 8.34 [4.70, 21.70] | 8.70 [7.05, 8.90] | 0.752 | |
| MEL (2) Median [Q1, Q3] [pg/mL] | 8.27 [4.50, 14.90] | 9.15 [7.79, 9.39] | 0.966 | |
Abbreviations: CG (0)—concentration of carbonyl groups determined within 4.5 h; CG (1)—concentration of carbonyl groups determined within 24 h; CG (2)—concentration of carbonyl groups determined within 7 days; MEL (0)—concentration of melatonin metabolite determined within 4.5 h; MEL (1)—concentration of melatonin metabolite determined within 24 h; MEL (2)—concentration of melatonin metabolite determined within 7 days.