Acronym	Full-Extensive name
ACAN	Aggrecan
ADAMTs	a disintegrin and metalloproteinase with thrombospondin motifs
AGEs	advanced glycation end-products
Arg1	arginase-1
BCP	basic calcium phosphate
BDNF	brain-derived neurotrophic factor
BDMs	bioactive dietary molecules
BDNF	brain-derived neurotrophic factor
CCL	Chemokine (C-C motif) ligand
CFA	complete Freund’s adjuvant
CGRP	calcitonin gene-related peptide
ChPF	Chondroitin Polymerizing Factor
CHSY-1	Chondroitin sulfate synthase 1
COX-2	cyclooxygenase-2
CPPD	Calcium pyrophosphate dihydrate
CRP	C-reactive protein
CSPG	Chondroitin sulfate proteoglycans
CXCL	C-X-C Motif Chemokine Ligand
DAMPs	damage-associated molecular patterns
DEC	Decorin core protein
DRG	dorsal root ganglia
ECM	extracellular matrix
EFSA	European Food Safety Authority
ERK	extracellular signal regulated kinase
FMN	Formononetin
GABA	Gamma-aminobutyric acid
GAGs	Glycosamminoglycans
GSH	reduced glutathione
GSSG	oxidized disulfide form glutathione
GSTA4-4	glutathione-s-tranferase A4-4
H2O2	produces hydrogen peroxide
HA	hyaluronic acid
HMGB1	high-mobility group box-1
HNE	4-hydroxynonenal
HNE	4-hydroxynonenal
IA	intra-articular
IL	Interleukin
IL1-R	interleukin-1 receptor
iNOS	inducible NO synthase
JNK	c-Jun NH2-terminal kinase
KOOS	Knee injury and Osteoarthritis Outcome Score
LGI	low-grade inflammation
MAPK	mitogen-activated protein kinase
MCP-1, CCL2	monocyte chemoattractant protein-1
MIA	mono-iodoacetate
miR	miRNA
MMPs	matrix metalloproteinases
MWT	mechanical withdrawal threshold
NE	nor-epinephrine
NF-κB	nuclear factor kappa-light-chain-enhancer of activated B cells
NGF	nerve growth factor
NK	neurokinin
NLRP3	nucleotide-binding oligomerization domain-like receptor protein 3
NLRs	NOD-like receptors
NMDA	N-methyl-D-aspartate
NO	nitric oxide
NOX	NADPH Oxidase
NSAIDs	non-steroidal anti-inflammatory drugs
OA	osteoarthritis
OSM	oncostatin M
PG	Proteoglycans
PGE2	prostaglandin E2
PI3K/ AKT	phosphoinositide 3-kinase/protein kinase B
PLGA	poly lactic-co-glycolic acid
PPs	polyphenols
PRP	Platelet-rich plasma
PRRs	pattern recognition receptors
PTGS2	prostaglandin-endoperoxide synthase 2
PWL	paw withdrawal latency
PWT	paw withdrawal threshold
RAGEs	receptor for advanced glycosylation end products
ReHo	Regional homogeneity
ROM	Range of motion
ROS	Reactive oxygen species
Rsv	Resveratol
Runx-2	runt-related transcription factor 2
SASP	senescence-associated secretory phenotype
Sox-9	SRY-box transcription factor 9
SP	substance P
TGF- β	transforming growth factor β
TBHP	tert-butylhydroperoxide
TKA	total knee arthroplasty
TLR	toll-like receptors
TNF-α	tumor necrosis factor-α
TRIF	TIRdomain-containing adaptor-inducing interferon-β
TrK	tropomyosin receptor kinase
TRP	Transient receptor potential
TrpV1	Transient receptor potential cation channel subfamily V member 1
TWL	thermal withdrawal latency
VAS	Visual Analogh scale
VEGF	vascular endothelial growth factor
WOMAC	Western Ontario and McMaster Universities Arthritis Index
XT	Xylosyltransferase
Ym1	chitinase 3-like protein 3