Figure 2.

Schematic representation of hematopoiesis. Hematopoietic stem cells (HSC) produce a common myeloid progenitor (CMP) cell, which can give raise to granulocyte-monocyte progenitor (GMP), monocyte-dendritic cell progenitor (MDP), or committed monocyte progenitor (cMoP) cells. GMPs differentiate into granulocyte progenitor (GP), which further differentiates into neutrophils. Dendritic cells (DC) are derived from a common dendritic cell progenitor (CDP). Monocytes can be derived directly from cMoP or from MDP, and they can further differentiate into macrophages or monocytic MDSC (m-MDSC), which can, in turn, switch to DC or macrophages.