Figure 4.

The effect of flavones on the innate immune cells in obesity and cancer. In obesity, flavones exhibit anti-inflammatory and anti-obesogenic action in adipose tissue (AT) by decreasing infiltration of dendritic cells (DC) and switching macrophage polarization to the M2 phenotype. The effect of flavones on myeloid-derived suppressor cells (MDSC) in obesity is not known. In cancer, flavones decrease infiltration of tumor-associated macrophages (TAM), reduce the number and function of MDSC, activate functionally deficient tumor-associated DC (TADC), and promote macrophage polarization toward the anti-tumor M1 phenotype. ↓—decrease, ↑—increase, ?—unknown.