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. 2022 Dec 13;23(24):15784. doi: 10.3390/ijms232415784

Figure 2.

Figure 2

hADC overexpression in mNPCs reduces glial scar volume 2 weeks after transplantation into compression-lesioned spinal cords of adult mice. (A) Immunohistochemistry of longitudinal spinal cord sections stained with antibodies against GFAP at T8, T9, and T10 at 2 weeks after transplantation of hADC overexpressing mNPCs (hADC-mNPCs), empty retroviral overexpression mNPCs (pLXSN-mNPCs), or mNPCs alone. The red box was the site of the glial scar lesion, and the middle of the glial scar is indicated by a red asterisk. Scale bar = 5 mm. (B) Lesion areas are significantly larger in mice with mNPC transplantation (45% of the area shown in part A) than transplantations of pLXSN-mNPCs (40% of the area shown in A) and hADC-mNPCs (19% of the area shown in A). Data are presented as means ± SEM. (n = 5 per sample, *** p < 0.001).