Table 2.

Summary of approved therapeutic drugs and vaccine against COVID-19 between the 1st wave and 7th wave in Japan.

Wave	Period	Approved drugs and vaccine
1st wave	January 2020 to May 2020
2nd wave	June 2020 to October 2020	Remdesivir Dexamethasone
3rd wave	November 2020 to March 2021	Baricitinib
4th wave (Alpha variant)	April 2021 to June 2021	Anti-SARS-CoV-2 vaccine BNT162b2 mRNA-1273 ChAdOx1 nCoV-19
5th wave (Delta variant)	July 2021 to December 2021	Casirivimab-imdevimab Sotrovimab
6th wave (Omicron subvariant BA.1 and BA.2)	January 2022 to June 2022	Molnupiravir Nirmatrelvir/ritonavir Tocilizumab
7th wave (Omicron subvariant BA.5)	July 2022 to November 2022	Tixagevimab/cilgavimab Ensitrelvir