Fig. 1.

Timeline showing the key dates in the development of thalidomide and its clinical use as an ‘anti-emetic’ (upper row; see text for references and details) and examples of key contemporaneous developments in the use of ‘anti-emetics’ to treat anti-cancer chemotherapy –induced nausea and vomiting (CINV). Sources are: Domperidone, Huys, 1978; Dexamethasone, Baker et al., 1979; Metoclopramide (high dose), Gralla et al. (1981); Granisetron, Cassidy et al., 1988; Aprepitant, Navari et al., 1999 (see References for details).