FIG. 2.

Effect of administration of anti-IL-18 during toxoplasmosis. SCID mice were infected i.p. with 20 ME-49 cysts and treated with a rabbit isotype control antibody or rabbit anti-IL-18 as described in Materials and Methods. The levels of IFN-γ in serum were measured by ELISA (A), and the percentage of PECs infected was estimated by using cytospins (B). The data shown are the means ± the SD of three pooled experiments with three to six mice per group (∗, P < 0.05). (C) NK cell (spleen) cytolytic activity against YAC-1 cells on day 7 postinfection were measured. The data shown are representative of three independent experiments.