Table 3.
Likelihood of receiving postoperative chemotherapy and multiagent regimens for young (ages 18–44 years) and older (ages 44–80 years) patients with colorectal cancer
| Stage | Receiving postoperative chemotherapy | Multiagent regimens | ||||
| N (%) | OR (95% CI)a | P valuec | N (%) | OR (95% CI)a | P valuec | |
| All stages | ||||||
| 44–80 yr | 2,722 (55.5) | 1 (Reference) | 2,269 (85.9) | 1 (Reference) | ||
| 18–44 yr | 171 (73.4) | 2.36 (1.71–3.25) | <0.001 | 155 (93.9) | 2.59 (1.35–5.00) | 0.014 |
| Stage I | ||||||
| 44–80 yr | 166 (21.8) | 1 (Reference) | 107 (68.2) | |||
| 18–44 yr | 13 (50.0) | 3.38 (1.49–7.66) | 0.002 | 7 (63.6) | NA | 0.757 |
| Overall stage II | ||||||
| 44–80 yr | 1,177 (55.1) | 1 (Reference) | 945 (82.4) | 1 (Reference) | ||
| 18–44 yr | 70 (72.2) | 2.19 (1.39–3.44) | 0.002 | 67 (97.1) | 7.18 (1.75–29.55) | 0.007 |
| Low-risk stage II | ||||||
| 44–80 yr | 777 (54.1) | 1 (Reference) | 632 (82.8) | |||
| 18–44 yr | 39 (67.2) | 1.78 (1.02–3.11) | 0.008 | 37 (97.4) | 7.66 (1.04–56.13) | 0.042 |
| High-risk stage II | ||||||
| 44–80 yr | 400 (57.0) | 1 (Reference) | 313 (81.5) | |||
| 18–44 yr | 31 (79.5) | 2.98 (1.35–6.58) | 0.008 | 30 (96.8) | 6.68 (0.90–49.80) | 0.048 |
| Stage III | ||||||
| 44–80 yr | 1,225 (71.1) | 1 (Reference) | 1,082 (91.4) | |||
| 18–44 yr | 74 (84.1) | 2.65 (1.39–5.06) | 0.009 | 68 (95.8) | NAb | 0.271 |
| Stage IV | ||||||
| 44–80 yr | 154 (54.0) | 135 (88.2) | ||||
| 18–44 yr | 14 (63.6) | NAb | 0.383 | 13 (92.9) | NAb | 0.702 |
CI, confidence interval; MMR, mismatch repair; NA, not applicable; OR, odds ratio; TNM, tumour, node, and metastasis.
a
Multivariable logistic regression model adjusted for sex, differentiation grade, TNM stage, location, perineural invasion, vascular invasion, and MMR status.
b
Variables were not included in multivariable analysis.
c
P values were corrected using the Benjamini-Hochberg method.