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. 2022 Dec 19;39(12):3099–3111. doi: 10.1007/s11095-022-03450-4

Table II.

The list of organic solvents categorized by the shape of mefenamic acid crystals they can produce

Polyhedral Needle Supersaturation dependent (polyhedral supersaturation range, needle supersaturation range)
1,2 dichloroethane 1-bromobutane 1,4 dioxane (1.18 – 1.28, 1.39 – 1.91)
1-chlorobutane 1-methylnaphtalene 2-butanol (1.51 – 1.83, 1.94 – 2.03)
1-octanol aniline 2-butanone (1.10 – 1.50, 1.60 – 2.01)
2-methoxyethanol anisole 2-propanol (1.14 – 1.41, 1.49 – 1.99)
acetic acid methyl acetate butyl acetate (1.32, 1.42 – 2.00)
acetone nitromethane diethyl sulfide (1.06 – 1.57, 1.76 – 1.94)
acetonitrile toluene Methanol (1.13 – 1.22, 1.30 – 1.98)
chloroform
ethanol
DMF
ethyl acetate
iodomethane
triethylamine
trichloroethylene