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SSE Statistics on the Ability of the Different Experimental Designs to Discriminate Between EC50 and Emax Interactions
| Reference designs | Rhombic designs | ||||
|---|---|---|---|---|---|
| conventional | EC 4 × 4 | fixed | free | ||
| rich | sparse | ||||
| Combination scenarios | 81 | 9 | 9 | 4 | 4 |
| Min. AICa difference for interaction discrimination (EC50, Emax) in ≥ 95% of the simulations | 47.83 | 0.81 | 15.24 | 9.22 | 5.52 |
aAIC, Akaike Information criterion
