Table 1.

Key questions in the field of Acute Stress Reaction (ASR) management

Question
What is the full range of ASR symptoms?
What are the most common ASR symptoms? What is the prevalence of ASR symptoms?
Do ASR symptoms co-vary?
What are the most common ASR phenotypes?
What is the relationship between ASR symptoms/ phenotypes and chronic symptom development?
What is the relationship between ASR symptoms/ phenotypes and the risk of ASD/ PTSD onset?
What are the neurophysiological underpinnings of ASR symptoms? Do they differ for active versus passive symptoms? Are different medications needed to address active versus passive symptoms?
What are the predictors of ASR symptoms?
Do men and women differ in their ASR symptom presentations? Do the neurophysiological underpinnings of ASR symptoms differ between men and women?
How do we effectively assess the severity of ASRs? Is there a threshold for medication administration? Can we use the same standards to monitor medication efficacy or lack thereof?
If an ASR occurs in parallel with trauma, is intervention beneficial or detrimental for long-term responses?
If ASR symptoms re-occur will additional dosing with initial medication attenuate symptoms? What symptoms may be treatment resistant?