TABLE 2.
Donor culture results stratified by donor history of recent injection drug use (IDU)
| Donor culturea | Donor with recent history of IDU (N = 66) |
Donor with no history of recent IDU (N = 328) |
p-Value |
|---|---|---|---|
| Any positive cultureb | 63 (95%) | 280 (85%) | .03 |
| Any positive hospital culturec | 44 (67%) | 199 (61%) | .36 |
| Any positive OPO cultured | 236 (72%) | 55 (83%) | .06 |
| Sites of positive cultures | |||
| Positive blood culture | 6 (9%) | 37 (11%) | .60 |
| Positive respiratory culturee | 60 (91%) | 266 (81%) | .05 |
| Positive respiratory culture in lung recipient (positive allograft culture)e | 17 (89%) | 92 (82%) | .43 |
| Positive genitourinary culturef | 12 (18%) | 63 (19%) | .85 |
| Positive genitourinary culture in kidney recipient (positive allograft culture)f | 8 (13%) | 49 (23%) | .06 |
| Positive perfusate cultureg | 6 (9%) | 23 (7%) | .56 |
| Organism identified on donor cultures | |||
| Staphylococcus aureus | 32 (48%) | 135 (41%) | .27 |
| Candida spp. | 26 (39%) | 86 (26%) | .03 |
| Candida on respiratory culture | 21 (32%) | 76 (23%) | .14 |
| Candida on GU culture | 8 (12%) | 15 (5%) | .051 |
| Candida on perfusate culture | 2 (3%) | 3 (1%) | .20 |
| Candida on blood culture | 0 (0%) | 5 (2%) | .60 |
| Candida on abdominal culture | 0 (0%) | 1 (0.3%) | >.99 |
| Candida on pleural culture | 0 (0%) | 1 (0.3%) | >.99 |
| Coagulase-Negative Staphylococcus | 7 (11%) | 38 (12%) | .82 |
| Klebsiella pneumonia | 4 (6%) | 34 (10%) | .36 |
| Haemophilus influenza | 5 (8%) | 34 (10%) | .65 |
| Escherichia coli | 2 (3%) | 29 (9%) | .14 |
| Enterobacter spp. | 4 (6%) | 21 (6%) | >.99 |
| Enterococcus spp. | 2 (3%) | 20 (6%) | .55 |
| Non-Group A Beta-Hemolytic Streptococci | 3 (5%) | 18 (5%) | >.99 |
| Pseudomonas aeruginosa | 1 (2%) | 21 (6%) | .15 |
| MDROs identified on donor cultures | |||
| Any MDROh | 9 (14%) | 49 (15%) | .06 |
| MRSA | 8 (12%) | 28 (9%) | .36 |
| VRE | 0 (0%) | 3 (1%) | >.99 |
| ESBL-Enterobacterales | 1 (2%) | 19 (6%) | .22 |
| CRE | 0 (0.00%) | 1 (0%) | >.99 |
| MDR-Pseudomonas | 0 (0%) | 2 (1%) | >.99 |
Abbreviations: CRE, carbapenem-resistant Enterobacterales; ESBL, extended-spectrum beta-lactamases; IDU, injection drug use; MDR, multidrug-resistant; MDRO, multidrug-resistant organism; MRSA, methicillin-resistant Staphylococcus aureus; OPO, organ procurement organization; spp., species; VRE, vancomycin-resistant Enterococcus.
Data are presented as numbers (percentages) except where noted.
Routine mouth flora on respiratory cultures and mixed flora on urine cultures were excluded.
Hospital cultures were obtained during the donor’s terminal hospitalization, and results may have been known prior to organ procurement.
OPO cultures were collected at the time of organ procurement, and results would not have been known until after transplantation..
Respiratory cultures included sputum cultures, tracheal aspirate cultures, endotracheal tube aspirate cultures, bronchial cultures, and bronchoalveolar lavage cultures. A positive respiratory culture in a lung recipient is a “positive allograft culture.”
Genitourinary cultures included urine cultures and ureter swab cultures. A positive genitourinary culture in a kidney recipient is a “positive allograft culture.”
Perfusate cultures included perfusate fluid cultures, transport fluid cultures, and pump solution cultures.
MDROs included MRSA, ESBL-Enterobacterales, CRE, MDR-Pseudomonas, and VRE. MDR-Acinetobacter was also included, but there were no donors who had this MDRO identified on culture.