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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2022 Nov 3;43(1):79–91. doi: 10.1161/ATVBAHA.121.317735

Figure 3. Platelets from aged pSOD2-KO mice show exacerbated mitochondrial hyperpolarization and enhanced annexin V binding.

Figure 3.

Washed platelets were prepared from young or aged mice deficient in platelet SOD2 (pSOD2-KO) or littermate controls and respective fluorescence upon treatment was measured by flow cytometry and normalized to respective young control without treatment. A. TMRM fluorescence was measured in resting platelets in the presence and absence of FCCP. B. Annexin V binding was quantified in resting and thrombin and convulxin activated platelets. Data are presented as median with 95% CI and analyzed by Kruskal-Wallis test with Dunn’s post hoc test for multiple group comparisons within each treatment group. N = 5 per group.