Figure 5: Deficiency of platelet SOD2 increases susceptibility to thrombosis in aged mice.
The time to first (A) and stable occlusion (B) of the carotid artery following photochemical injury, and (C) time to death after collagen infusion, was measured in young and aged platelet-specific pSOD2-KO mice or control littermates. Data for A and B are presented as mean ± SE and analyzed using two-way ANOVA with Tukey’s analysis for multiple group comparisons. Data for C is presented as median with 95% CI and analyzed by Kruskal-Wallis test with Dunn’s post hoc test for multiple group comparisons. D. Survival curve after collagen infusion and is analyzed using Log-rank (Mantel-Cox) test. N = 8–13 per group.